POLM antibody (Middle Region)

Catalog No. ABIN2785958

Product Details anti-POLM Antibody

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Pig, Rabbit, Rat, Horse, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLM antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRRFSRKEKG LWLNSHGLFD PEQKTFFQAA SEEDIFRHLG LEYLPPEQRN

Predicted Reactivity: Cow: 79%, Dog: 92%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against POLM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POLM

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 494 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLM

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Alternative Name: POLM (POLM Products)

Synonyms: polmu antibody, zgc:56122 antibody, POLM antibody, Pol Mu antibody, Tdt-N antibody, AI462166 antibody, B230309I03Rik antibody, polymerase (DNA directed), mu antibody, DNA polymerase mu antibody, polm antibody, POLM antibody, CC1G_09351 antibody, VDBG_09335 antibody, Polm antibody

Background: POLM seems to act as an Ig mutase which is responsible for immunoglobulin (Ig) gene hypermutation.
Alias Symbols: Tdt-N, Pol Mu
Protein Interaction Partner: CEP55, IKZF3, PNMA1, PCNA, UBE2C, UBE2H, UBE2E1, UBE2D3, UBE2D2, UBE2D1,
Protein Size: 494

Molecular Weight: 55 kDa

Gene ID: 27434

NCBI Accession: NM_013284, NP_037416

UniProt: Q9NP87

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response