CARD8 antibody (N-Term)

Catalog No. ABIN2786065

Product Details anti-CARD8 Antibody

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LGGTFPGDIC SEENQIVSSY ASKVCFEIEE DYKNRQFLGP EGNVDVELID

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CARD8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CARD8

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Alternative Name: CARD8 (CARD8 Products)

Synonyms: CARD8 antibody, CARDINAL antibody, DACAR antibody, DAKAR antibody, NDPP antibody, NDPP1 antibody, TUCAN antibody, caspase recruitment domain family, member 8 antibody, caspase recruitment domain-containing protein 8 antibody, caspase recruitment domain family member 8 antibody, CARD8 antibody, LOC718594 antibody

Background: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Protein Interaction Partner: ELAVL1, CARD16, CARD8, CARD18, NLRP2, NLRP3, FHL2, CASP9, IKBKG, CASP1, CARD6,
Protein Size: 286

Molecular Weight: 31 kDa

Gene ID: 22900

Pathways: Positive Regulation of Endopeptidase Activity