SPG20 antibody (Middle Region)

Catalog No. ABIN2786078

Product Details anti-SPG20 Antibody

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG20 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ASWVSWGLVK GAEITGKAIQ KGASKLRERI QPEEKPVEVS PAVTKGLYIA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SPG20. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SPG20

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 666 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPG20

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Alternative Name: SPG20 (SPG20 Products)

Synonyms: SPARTIN antibody, TAHCCP1 antibody, AI840044 antibody, C79168 antibody, mKIAA0610 antibody, spartin antibody, Spg20 antibody, spg20a antibody, zgc:172059 antibody, spg20b antibody, zgc:153766 antibody, spartin antibody, spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) antibody, spartin a antibody, spartin b antibody, SPART antibody, Spg20 antibody, Spart antibody, sparta antibody, spartb antibody

Background: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Alias Symbols: KIAA0610, SPARTIN, TAHCCP1
Protein Interaction Partner: UBC, WWOX, ITCH, PLIN3, SMURF2, ZFYVE9, APP, EPS15, SMURF1, WWP2, WWP1, SUMO2, KLC2, AIFM1, VIM, NCL, LMNB1, KPNB1, KIF5B, HSPD1, HSPA9, HSPA5, HADHA, ACSL4, ACSL3, DYNC1H1, COPA, CLTC, TUBA1A,
Protein Size: 666

Molecular Weight: 73 kDa

Gene ID: 23111

NCBI Accession: NM_015087, NP_055902

UniProt: Q8N0X7

Pathways: Regulation of Cell Size, SARS-CoV-2 Protein Interactome