AGTPBP1 antibody (C-Term)

Catalog No. ABIN2786096

Product Details anti-AGTPBP1 Antibody

Target: AGTPBP1 (ATP/GTP Binding Protein 1 (AGTPBP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGTPBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GMQPLMYSVQ EALNARPWWI RMGTDICYYK NHFSRSSVAA GGQKGKSYYT

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against Agtpbp1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Agtpbp1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1160 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AGTPBP1

Target: AGTPBP1 (ATP/GTP Binding Protein 1 (AGTPBP1))

Alternative Name: Agtpbp1 (AGTPBP1 Products)

Synonyms: ccp1 antibody, AGTPBP1 antibody, CCP1 antibody, NNA1 antibody, 1700020N17Rik antibody, 2310001G17Rik antibody, 2900054O13Rik antibody, 4930445M19Rik antibody, 5730402G09Rik antibody, BB114605 antibody, Nna1 antibody, mKIAA1035 antibody, nmf243 antibody, pcd antibody, si:ch73-236b16.2 antibody, ATP/GTP binding protein 1 L homeolog antibody, ATP/GTP binding protein 1 antibody, agtpbp1.L antibody, AGTPBP1 antibody, agtpbp1 antibody, Agtpbp1 antibody

Background: Agtpbp1 is a metallocarboxypeptidase that mediates deglutamylation of target proteins. It catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. It also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Agtpbp1 acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.
Alias Symbols: 1700020N17Rik, 2310001G17Rik, 2900054O13Rik, 4930445M19Rik, 5730402G09Rik, BB114605, CCP1, Nna1, mKIAA1035, nmf243, pcd
Protein Size: 1160

Molecular Weight: 128 kDa

Gene ID: 67269

NCBI Accession: NM_023328, NP_075817

Pathways: Proton Transport