COG4 antibody (Middle Region)

Catalog No. ABIN2786106

Product Details anti-COG4 Antibody

Target: COG4 (Component of Oligomeric Golgi Complex 4 (COG4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COG4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TSLVAVELEK VVLKSTFNRL GGLQFDKELR SLIAYLTTVT TWTIRDKFAR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against COG4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COG4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 789 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-COG4 antibody (ABIN2786106)

Suzuki, Fujisawa, Ando, Niino, Ohsawa, Shimokata, Ohta: "Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae." in: Neurology, Vol. 63, Issue 9, pp. 1711-3, (2004) (PubMed).

Target Details for COG4

Target: COG4 (Component of Oligomeric Golgi Complex 4 (COG4))

Alternative Name: COG4 (COG4 Products)

Synonyms: COG4 antibody, DKFZp470I1314 antibody, CDG2J antibody, COD1 antibody, AW554810 antibody, D8Ertd515e antibody, zgc:136860 antibody, component of oligomeric golgi complex 4 antibody, COG4 antibody, cog4 antibody, Cog4 antibody

Background: Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4.Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002 [PubMed 11980916]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-265 AK096557.1 1-265 266-555 BP282697.1 230-519 556-1072 AU125729.1 34-550 1073-2838 AL050101.1 375-2140
Alias Symbols: COD1, DKFZp586E1519, CDG2J
Protein Interaction Partner: UBC, EGFR, COG6, VCP, COG7, COG8, COG3, COG5, COG1, RPS20, CUL4B, SEPT2, APC, COG2,
Protein Size: 789

Molecular Weight: 89 kDa

Gene ID: 25839

NCBI Accession: NM_015386, NP_056201

UniProt: Q9H9E3