NUP43 antibody (Middle Region)

Catalog No. ABIN2786439

Product Details anti-NUP43 Antibody

Target: NUP43 (Nucleoporin 43kDa (NUP43))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUP43 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HQSVISSWLS TDPAKDRIEI TSLLPSRSLS VNTLDVLGPC LVCGTDAEAI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NUP43. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NUP43

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 380 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NUP43 antibody (ABIN2786439)

Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, (2005) (PubMed).

Target Details for NUP43

Target: NUP43 (Nucleoporin 43kDa (NUP43))

Alternative Name: NUP43 (NUP43 Products)

Synonyms: MGC184722 antibody, MGC154553 antibody, 2610016K01Rik antibody, 2610529I12Rik antibody, AA409950 antibody, p42 antibody, bA350J20.1 antibody, nucleoporin 43 antibody, nucleoporin 43kDa antibody, nucleoporin Nup43 antibody, nucleoporin 43kDa S homeolog antibody, NUP43 antibody, nup43 antibody, LOC696374 antibody, nup43.S antibody, Nup43 antibody

Background: NUP43 is the component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 BG567254.1 2-11 11-24 CB989591.1 28-41 25-47 AK074311.1 1-23 48-1751 AF514997.1 1-1704 1752-2581 BC047539.1 2681-3510 2582-2745 BC046637.1 2350-2513 2746-2818 BG527619.1 33-105 c 2819-3862 BC046637.1 2587-3630
Alias Symbols: FLJ13287, bA350J20.1, p42
Protein Interaction Partner: UBC, SUMO1, SEH1L, DCTN2, TP53RK, RAB3GAP2, NUP107, UBD, ISG15, CUL4A, DDB1, Nup98, NUP37, NUP85, NUP133, NUP160,
Protein Size: 380

Molecular Weight: 42 kDa

Gene ID: 348995

NCBI Accession: NM_198887, NP_942590

UniProt: Q8NFH3