PSMB2 antibody (Middle Region)

Catalog No. ABIN2786716

Product Details anti-PSMB2 Antibody

Target: PSMB2 (Proteasome (Prosome, Macropain) Subunit, beta Type 2 (PSMB2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LDRYYTPTIS RERAVELLRK CLEELQKRFI LNLPTFSVRI IDKNGIHDLD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PSMB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 201 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMB2

Target: PSMB2 (Proteasome (Prosome, Macropain) Subunit, beta Type 2 (PSMB2))

Alternative Name: PSMB2 (PSMB2 Products)

Synonyms: HC7-I antibody, 19.m02268 antibody, DDBDRAFT_0190287 antibody, DDBDRAFT_0232958 antibody, DDB_0190287 antibody, DDB_0232958 antibody, Psmb2 antibody, ACYPI004276 antibody, AU045357 antibody, AW108089 antibody, C7-I antibody, D4Wsu33e antibody, zgc:92282 antibody, proteasome subunit beta 2 antibody, proteasome subunit beta type 2 antibody, proteasome beta 2 subunit antibody, putative proteasome beta 2 subunit antibody, 20S proteasome subunit beta-2 antibody, proteasome (prosome, macropain) subunit, beta type 2 antibody, proteasome subunit beta 2 L homeolog antibody, PSMB2 antibody, CNC04990 antibody, Tc00.1047053510287.30 antibody, Tc00.1047053503891.100 antibody, Tc00.1047053508461.430 antibody, LBRM_34_3820 antibody, LBRM_35_0400 antibody, BBOV_I004450 antibody, LMJF_36_0320 antibody, psmB2 antibody, Psmb2 antibody, psmb2 antibody, psmb2.L antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB2 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HC7-I, MGC104215, MGC126885
Protein Interaction Partner: KCTD9, UBC, KRT13, PSMD14, ASB11, POMP, PSMB8, PSMB7, PSMB6, PSMB5, PYCRL, PSMB4, PSMB3, PSMB1, PSMA7, PSMA6, PSMA5, PSMA4, PSMA3, PSMA1, HOXA2, PSMA2, PARK2, CDK20, ITGA4, GPX2, FN1, DDX49, IQCB1, VCAM1, SULT1A4, TUBB, PSMA8, C11orf58, SEC23A, PSME3, PSM
Protein Size: 201

Molecular Weight: 23 kDa

Gene ID: 5690

NCBI Accession: NM_002794, NP_002785

UniProt: P49721

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA