RAGE antibody (N-Term)

Catalog No. ABIN2786877

Product Details anti-RAGE Antibody

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAGE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MKQRFESIEQ VNNLREIQAL RRLNPHPNIL MLHEVVFDRK SGSLALICEL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RAGE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RAGE

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 419 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-RAGE antibody (ABIN2786877)

Tafani, Schito, Pellegrini, Villanova, Marfe, Anwar, Rosa, Indelicato, Fini, Pucci, Russo: "Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B." in: Carcinogenesis, Vol. 32, Issue 8, pp. 1167-75, (2011) (PubMed).

Target Details for RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Alternative Name: RAGE (AGER Products)

Synonyms: RAGE antibody, AGER antibody, advanced glycosylation end-product specific receptor antibody, advanced glycosylation end product-specific receptor antibody, MAPK/MAK/MRK overlapping kinase antibody, AGER antibody, Ager antibody, LOC719012 antibody

Background: RAGE is able to phosphorylate several exogenous substrates and to undergo autophosphorylation.
Alias Symbols: MOK, RAGE1, RAGE, RAGE-1
Protein Interaction Partner: UBC, WDR18, SDF4, HUWE1, ZNF223, MOK, INSR, MAPK6, MYC, JUN, CCNB1,
Protein Size: 419

Molecular Weight: 48 kDa

Gene ID: 5891

NCBI Accession: NM_013401, NP_055041

UniProt: Q9UQ07

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins