SMARCD3 antibody (C-Term)

Catalog No. ABIN2787637

Product Details anti-SMARCD3 Antibody

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DLKVMTDVAG NPEEERRAEF YHQPWSQEAV SRYFYCKIQQ RRQELEQSLV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Smarcd3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 483 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMARCD3

Target: SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 (SMARCD3))

Alternative Name: Smarcd3 (SMARCD3 Products)

Synonyms: SMARCD3 antibody, baf60c antibody, cracd3 antibody, rsc6p antibody, BAF60C antibody, CRACD3 antibody, Rsc6p antibody, 1500001J14Rik antibody, 2210409C08Rik antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 S homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b antibody, SMARCD3 antibody, smarcd3.S antibody, Smarcd3 antibody, smarcd3b antibody

Background: Smarcd3 plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. It stimulates nuclear receptor mediated transcription. It belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Alias Symbols: 1500001J14Rik, 2210409C08Rik, BAF60C
Protein Interaction Partner: Ikzf1, Smad4, Smad1, Gata4, Smarca2, Smarca4, Rbpj, Notch1,
Protein Size: 483

Molecular Weight: 55 kDa

Gene ID: 66993

NCBI Accession: NM_025891, NP_080167

UniProt: Q6P9Z1

Pathways: Regulation of Lipid Metabolism by PPARalpha