TINF2 antibody (Middle Region)

Catalog No. ABIN2787641

Product Details anti-TINF2 Antibody

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Pig, Rat, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TINF2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SDEEENGQGE GKESLENYQK TKFDTLIPTL CEYLPPSGHG AIPVSSCDCR

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against TINF2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TINF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 451 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TINF2

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Alternative Name: TINF2 (TIN2 Products)

Synonyms: DKCA3 antibody, TIN2 antibody, AW552114 antibody, D14Wsu146e antibody, Tin2 antibody, TERF1 interacting nuclear factor 2 antibody, Terf1 (TRF1)-interacting nuclear factor 2 antibody, TINF2 antibody, Tinf2 antibody

Background: TINF2 is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. It plays a role in shelterin complex assembly.
Alias Symbols: TIN2, DKCA3
Protein Interaction Partner: ACD, TERF2, TPP1, ANXA8L1, TNKS, TERF1, VIPR1, ZNF790, PAGE2, TUBB, DHFRL1, APOBEC3F, REM2, NUDCD2, CCDC43, SCRN2, TRIM15, TXNDC17, AFAP1L2, FERMT3, KCTD17, ANKMY2, PPP6R3, PGM2, APPL2, BIN2, LGALSL, PHPT1, GNMT, OR2H1, CCDC9, POT1, AIPL1, NCDN, ACOT7, TO
Protein Size: 451

Molecular Weight: 50 kDa

Gene ID: 26277

NCBI Accession: NM_001099274, NP_001092744

UniProt: Q9BSI4

Pathways: Cell Division Cycle, Telomere Maintenance, Regulation of Carbohydrate Metabolic Process