COL1A2 antibody (Middle Region)
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- Target See all COL1A2 Antibodies
- COL1A2 (Collagen, Type I, alpha 2 (COL1A2))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Dog, Rabbit, Cow, Zebrafish (Danio rerio), Goat, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This COL1A2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- PGSVGPAGPR GPAGPSGPAG KDGRTGHPGT VGPAGIRGPQ GHQGPAGPPG
- Predicted Reactivity
- Cow: 100%, Dog: 93%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 100%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against COL1A2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human COL1A2
- Top Product
- Discover our top product COL1A2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1366 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- COL1A2 (Collagen, Type I, alpha 2 (COL1A2))
- Alternative Name
- COL1A2 (COL1A2 Products)
- Synonyms
- AA960264 antibody, AI325291 antibody, Col1a-2 antibody, Cola-2 antibody, Cola2 antibody, oim antibody, OI4 antibody, Gas-6 antibody, alpha2(I) antibody, hm:zehn2357 antibody, wu:fa98d05 antibody, wu:fa99g10 antibody, wu:fb04c08 antibody, wu:fb11d06 antibody, zehn2357 antibody, coagulation factor II, thrombin antibody, collagen, type I, alpha 2 antibody, collagen type I alpha 2 chain antibody, collagen type I alpha 2 L homeolog antibody, growth arrest specific 6 antibody, F2 antibody, Col1a2 antibody, col1a2.L antibody, COL1A2 antibody, Gas6 antibody, col1a2 antibody
- Background
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COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: OI4
Protein Interaction Partner: UBQLN1, SGTA, PDGFB, PDGFA, COL1A1, PAN2, LIG4, MYOC, SHBG, UBC, MMP9, COL5A3, CD44, APP, P4HB, ITGA2B, TGFBI, LUM, BGN, VWF, ITGA2, SPARC, CD36, ITGB3, FN1, DCN, CD93,
Protein Size: 1366 - Molecular Weight
- 150 kDa
- Gene ID
- 1278
- NCBI Accession
- NM_000089, NP_000080
- UniProt
- P08123
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