WDR77 antibody (N-Term)
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- Target See all WDR77 Antibodies
- WDR77 (WD Repeat Domain 77 (WDR77))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WDR77 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against WDR77. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human WDR77
- Top Product
- Discover our top product WDR77 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 342 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- WDR77 (WD Repeat Domain 77 (WDR77))
- Alternative Name
- WDR77 (WDR77 Products)
- Synonyms
- MEP-50 antibody, MEP50 antibody, Nbla10071 antibody, RP11-552M11.3 antibody, p44 antibody, p44/Mep50 antibody, 2610003I18Rik antibody, 2610312E17Rik antibody, C79984 antibody, p44/MEP50 antibody, RGD1310479 antibody, mep50 antibody, valois antibody, WDR77 antibody, zgc:65780 antibody, zgc:77274 antibody, WD repeat domain 77 antibody, WD repeat domain 77 S homeolog antibody, WDR77 antibody, Wdr77 antibody, wdr77.S antibody, wdr77 antibody
- Background
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WDR77 is the non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. WDR77 might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Alias Symbols: HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44, MEP-50, p44/Mep50
Protein Interaction Partner: TP53, CUL3, SMAD1, AR, UBC, ASB15, WWOX, ZBTB1, SMYD1, COPS4, COPS7A, DCAF8, COPS8, PRMT5, TBC1D4, EPB41L2, HGS, FBXO6, PAN2, SNRPC, PPP1R8, POLR2C, PCBP2, HNRNPM, GRB2, QKI, TOE1, PPIL1, SAP30BP, LSM3, GPKOW, SF3A1, SF3B4, RBM5, PQBP1, THOC1, AQR, BAG2,
Protein Size: 342 - Molecular Weight
- 38 kDa
- Gene ID
- 79084
- NCBI Accession
- NM_024102, NP_077007
- UniProt
- Q9BQA1
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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