ALDH1A1 antibody (Middle Region)

Catalog No. ABIN2787809

Product Details anti-ALDH1A1 Antibody

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Sheep, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SVERAKKYIL GNPLTPGVTQ GPQIDKEQYD KILDLIESGK KEGAKLECGG

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 93%, Sheep: 93%, Yeast: 77%

Characteristics: This is a rabbit polyclonal antibody against ALDH1A1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ALDH1A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 501 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ALDH1A1

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Alternative Name: ALDH1A1 (ALDH1A1 Products)

Synonyms: ALDC antibody, ALDH-E1 antibody, ALDH1 antibody, ALDH11 antibody, PUMB1 antibody, RALDH1 antibody, AL1A1 antibody, aldc antibody, aldh-e1 antibody, aldh1 antibody, aldh11 antibody, pumb1 antibody, raldh1 antibody, GGADHR antibody, ALDH1A1 antibody, ALDDH antibody, Ahd2 antibody, Aldh1 antibody, Aldh2 antibody, Ahd-2 antibody, Aldh1a2 antibody, E1 antibody, Raldh1 antibody, Aldh1a1 antibody, ALHDII antibody, RALDH 1 antibody, RalDH1 antibody, aldehyde dehydrogenase 1 family member A1 antibody, aldehyde dehydrogenase 1 family, member A1 antibody, aldehyde dehydrogenase 1 family member A1 L homeolog antibody, aldehyde dehydrogenase family 1, subfamily A1 antibody, aldehyde dehydrogenase antibody, retinal dehydrogenase 1 antibody, ALDH1A1 antibody, aldh1a1 antibody, Aldh1a1 antibody, aldh1a1.L antibody, aldH1 antibody, LOC100732581 antibody, LOC101822890 antibody

Background: This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes.
Alias Symbols: ALDC, ALDH-E1, ALDH1, ALDH11, MGC2318, PUMB1, RALDH1
Protein Interaction Partner: ALDH1A1, SUMO1, NEDD8, NUPR1, POT1, NOS2, ALDH2, UBC,
Protein Size: 501

Molecular Weight: 55 kDa

Gene ID: 216

NCBI Accession: NM_000689, NP_000680

UniProt: P00352

Pathways: Dopaminergic Neurogenesis