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Caspase 4 antibody (Middle Region)

CASP4 Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2787904
  • Target See all Caspase 4 (CASP4) Antibodies
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Binding Specificity
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 58
    • 33
    • 15
    • 14
    • 1
    Human, Rat
    Host
    • 78
    • 10
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 77
    • 13
    Polyclonal
    Conjugate
    • 53
    • 15
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This Caspase 4 antibody is un-conjugated
    Application
    • 74
    • 29
    • 27
    • 12
    • 9
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG
    Predicted Reactivity
    Human: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CASP4. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CASP4
    Top Product
    Discover our top product CASP4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 377 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Alternative Name
    CASP4 (CASP4 Products)
    Synonyms
    ICE(rel)II antibody, ICEREL-II antibody, ICH-2 antibody, Mih1/TX antibody, TX antibody, Casp11 antibody, CASP13 antibody, CASP1 antibody, CASP4 antibody, Caspl antibody, ich-3 antibody, Casp4 antibody, caspase 4 antibody, caspase 4, apoptosis-related cysteine peptidase antibody, caspase-4 antibody, CASP4 antibody, Casp4 antibody, LOC100731032 antibody
    Background
    This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
    Alias Symbols: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
    Protein Interaction Partner: MYH9, ELF4, APP, TRAF6, PLA2G4A, NOD1, CASP14, CASP4, APAF1, SERPINB9, CASP10, IL18, CASP3, IL1B, DSP, PSEN1, IL37, CASP8, CASP1, XIAP, MYCBPAP, SLC25A22, SRPRB, CTNNBIP1, DNAAF5, MTHFD1L, UFL1, GCN1L1, SMC2, NUP93, SMC3, SMC1A, USP9X, VDAC3, PSMB1, MSH6,
    Protein Size: 377
    Molecular Weight
    10 kDa
    Gene ID
    837
    NCBI Accession
    NM_001225, NP_001216
    UniProt
    P49662
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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