TXNIP antibody (N-Term)

Catalog No. ABIN2787923

Product Details anti-TXNIP Antibody

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QTSEYLRYED TLLLEDQPTG ENEMVIMRPG NKYEYKFGFE LPQGPLGTSF

Predicted Reactivity: Cow: 79%, Dog: 100%, Guinea Pig: 87%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TXNIP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TXNIP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TXNIP (TXNIP Products)

Synonyms: EST01027 antibody, HHCPA78 antibody, THIF antibody, VDUP1 antibody, Gm348 antibody, Trf3 antibody, TBP2 antibody, TRF3 antibody, 1200008J08Rik antibody, AA682105 antibody, Hyplip1 antibody, Tbp-2 antibody, Vdup1 antibody, sb:cb368 antibody, txnip antibody, thioredoxin interacting protein antibody, TATA box binding protein like 2 antibody, TATA-box binding protein like 2 antibody, thioredoxin interacting protein L homeolog antibody, thioredoxin interacting protein a antibody, TXNIP antibody, Tbpl2 antibody, TBPL2 antibody, Txnip antibody, txnip.L antibody, txnip antibody, txnipa antibody

Background: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.
Protein Interaction Partner: UBC, DDIT4, ECD, TXN, TP53, SMURF2, UL49, ITCH, ELAVL1, FHL1, ZBTB32, ZBTB16, SCEL, HDAC1, TXNRD1, KPNA2,
Protein Size: 391

Molecular Weight: 43 kDa

Gene ID: 10628

NCBI Accession: XP_003960219

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome