SERPINB8 antibody (C-Term)

Catalog No. ABIN2787992

Product Details anti-SERPINB8 Antibody

Target: SERPINB8 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 (SERPINB8))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LVNAIYFKGK WNEQFDRKYT RGMLFKTNEE KKTVQMMFKE AKFKMGYADE

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SERPINB8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SERPINB8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 242 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SERPINB8

Target: SERPINB8 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8 (SERPINB8))

Alternative Name: SERPINB8 (SERPINB8 Products)

Synonyms: pi8 antibody, cap2 antibody, CAP-2 antibody, CAP2 antibody, NK10 antibody, Spi8 antibody, ovalbumin antibody, PI8 antibody, serpin family B member 8 antibody, serpin B8 antibody, serpin peptidase inhibitor, clade B (ovalbumin), member 8 antibody, serine (or cysteine) peptidase inhibitor, clade B, member 8 antibody, Serpinb8 antibody, SERPINB8 antibody, LOC607205 antibody, serpinb8 antibody, LOC100424017 antibody

Background: The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8, SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).
Alias Symbols: CAP2, PI8
Protein Interaction Partner: SUMO2, LARS, UBC, CAP1, PRSS1, F10, F2, FURIN, BCL2,
Protein Size: 242

Molecular Weight: 27 kDa

Gene ID: 5271

NCBI Accession: NM_001031848, NP_001027018

UniProt: Q8N178