Melanophilin antibody (C-Term)

Catalog No. ABIN2788093

Product Details anti-Melanophilin Antibody

Target: Melanophilin (MLPH)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Melanophilin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NLPIFLPRVA GKLGKRPEDP NADPSSEAKA MAVPYLLRRK FSNSLKSQGK

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MLPH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MLPH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 600 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Melanophilin

Target: Melanophilin (MLPH)

Alternative Name: MLPH (MLPH Products)

Synonyms: MGC155106 antibody, LOC100222096 antibody, 2210418F23Rik antibody, 5031433I09Rik antibody, AW228792 antibody, D1Wsu84e antibody, Slac-2a antibody, l(1)-3Rk antibody, l1Rk3 antibody, ln antibody, SLAC2-A antibody, melanophilin antibody, MLPH antibody, mlph antibody, Mlph antibody

Background: This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Alias Symbols: MGC2771, MGC59733, SLAC2-A
Protein Interaction Partner: CUL2, UBC, RAB27B, RAB27A, MYO5A, RAB10, RPH3A, ACTA1,
Protein Size: 600

Molecular Weight: 66 kDa

Gene ID: 79083

NCBI Accession: NM_024101, NP_077006

UniProt: Q9BV36