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Metabotropic Glutamate Receptor 3 antibody (C-Term)

GRM3 Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2788133
  • Target See all Metabotropic Glutamate Receptor 3 (GRM3) Antibodies
    Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))
    Binding Specificity
    • 16
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 40
    • 30
    • 13
    • 10
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat, Cow, Horse, Rabbit, Dog
    Host
    • 54
    • 2
    • 1
    Rabbit
    Clonality
    • 54
    • 3
    Polyclonal
    Conjugate
    • 24
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Metabotropic Glutamate Receptor 3 antibody is un-conjugated
    Application
    • 44
    • 20
    • 17
    • 10
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    RDFWEQKFQC SLQNKRNHRR VCDKHLAIDS SNYEQESKIM FVVNAVYAMA
    Predicted Reactivity
    Cow: 92%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against GRM3. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of human GRM3
    Top Product
    Discover our top product GRM3 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))
    Alternative Name
    GRM3 (GRM3 Products)
    Synonyms
    GLUR3 antibody, GPRC1C antibody, MGLUR3 antibody, mGlu3 antibody, 0710001G23Rik antibody, Gprc1c antibody, mGluR3 antibody, glutamate metabotropic receptor 3 antibody, glutamate receptor, metabotropic 3 antibody, GRM3 antibody, Grm3 antibody
    Background
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
    Alias Symbols: GLUR3, mGlu3, GPRC1C, MGLUR3
    Protein Size: 537
    Molecular Weight
    59 kDa
    Gene ID
    2913
    NCBI Accession
    NM_000840, NP_000831
    UniProt
    Q14832
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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