ARHGEF2 antibody (C-Term)

Catalog No. ABIN2788156

Product Details anti-ARHGEF2 Antibody

Target: ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Pig, Guinea Pig, Rabbit, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NTSPGVTANG EARTFNGSIE LCRADSDSSQ RDRNGNQLRS PQEEALQRLV

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARHGEF2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ARHGEF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 986 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARHGEF2

Target: ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))

Alternative Name: ARHGEF2 (ARHGEF2 Products)

Synonyms: MGC82333 antibody, MGC86214 antibody, MGC75855 antibody, AA408978 antibody, GEF antibody, GEF-H1 antibody, GEFH1 antibody, LFP40 antibody, Lbcl1 antibody, Lfc antibody, P40 antibody, mKIAA0651 antibody, GEF-H1/LFC antibody, Rho/Rac guanine nucleotide exchange factor 2 antibody, Rho/Rac guanine nucleotide exchange factor 2 S homeolog antibody, rho/rac guanine nucleotide exchange factor (GEF) 2 antibody, ARHGEF2 antibody, arhgef2.S antibody, arhgef2 antibody, Arhgef2 antibody

Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: DKFZp547L106, DKFZp547P1516, FLJ45440, GEF, GEF-H1, GEFH1, KIAA0651, LFP40, P40
Protein Interaction Partner: RPP25L, UBC, CEP250, RPA3, RPA2, RPA1, PPP6C, FBXO6, ANKRD28, PPP6R1, YWHAB, MMS19, PEX14, VCP, NOTCH1, YWHAZ, MARK2, RHOA, AKT1, USP21, ELAVL1, SUMO1, MARK4, YWHAH, YWHAG, MYC, MAPK1, TAF10, CGN, YWHAE, PAK1, RAC1, RRAS2, PLCG1, WASF1, YWHAQ,
Protein Size: 986

Molecular Weight: 111 kDa

Gene ID: 9181

NCBI Accession: NM_001162383, NP_001155855

UniProt: Q92974

Pathways: Negative Regulation of intrinsic apoptotic Signaling