Adenosine A3 Receptor antibody (C-Term)

Catalog No. ABIN2788278

Product Details anti-Adenosine A3 Receptor Antibody

Target: Adenosine A3 Receptor (ADORA3)

Binding Specificity: C-Term

Reactivity: Human, Pig, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenosine A3 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RSCKAPKVVR KADRSRTSIL IICILITGLG IISVISHLTK RRRSQRNRRV

Predicted Reactivity: Cow: 75%, Horse: 93%, Human: 100%, Pig: 85%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against ADORA3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ADORA3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 266 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Adenosine A3 Receptor antibody (ABIN2788278)

Merighi, Benini, Mirandola, Gessi, Varani, Leung, Maclennan, Baraldi, Borea: "Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells." in: Molecular pharmacology, Vol. 72, Issue 1, pp. 162-72, (2007) (PubMed).

Target Details for Adenosine A3 Receptor

Target: Adenosine A3 Receptor (ADORA3)

Alternative Name: ADORA3 (ADORA3 Products)

Synonyms: A3AR antibody, AD026 antibody, bA552M11.5 antibody, ADORA3 antibody, 1700001D09Rik antibody, 4930578J19Rik antibody, A3R antibody, AA3R antibody, ARA3 antibody, Gpcr2 antibody, adenosine A3 receptor antibody, adenosine receptor A3 antibody, ADORA3 antibody, Adora3 antibody, LOC100603318 antibody

Background: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: A3AR, AD026, bA552M11.5, RP11-552M11.7
Protein Interaction Partner: YWHAQ, YWHAZ,
Protein Size: 266

Molecular Weight: 30 kDa

Gene ID: 140

NCBI Accession: NM_001081976, NP_001075445

UniProt: Q5QNY7

Pathways: Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process