CYP8B1 antibody (Middle Region)

Catalog No. ABIN2788348

Product Details anti-CYP8B1 Antibody

Target: CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP8B1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLLWPREWLE VGRLQRLFHK MLSVSHSQEK EGISNWLGNM LQFLREQGVP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CYP8B1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CYP8B1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 501 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP8B1

Target: CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1))

Alternative Name: CYP8B1 (CYP8B1 Products)

Synonyms: MGC64456 antibody, CYP8B antibody, CP8B antibody, CYP12 antibody, cytochrome P450 family 8 subfamily B member 1 antibody, cytochrome P450 family 8 subfamily B member 1 S homeolog antibody, cytochrome P450, family 8, subfamily B, polypeptide 1 antibody, cytochrome P450, family 8, subfamily b, polypeptide 1 antibody, Cyp8b1 antibody, cyp8b1.S antibody, CYP8B1 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
Alias Symbols: CP8B, CYP12, FLJ17826
Protein Interaction Partner: UBC,
Protein Size: 501

Molecular Weight: 58 kDa

Gene ID: 1582

NCBI Accession: NM_004391, NP_004382

UniProt: Q9UNU6