Calpain 3 antibody (Middle Region)

Catalog No. ABIN2788628

Product Details anti-Calpain 3 Antibody

Target: Calpain 3 (CAPN3)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Sheep, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPQPQPGSSD QESEEQQQFR NIFKQIAGDD MEICADELKK VLNTVVNKHK

Predicted Reactivity: Cow: 75%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Rat: 79%, Sheep: 75%

Characteristics: This is a rabbit polyclonal antibody against CAPN3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 309 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Calpain 3

Target: Calpain 3 (CAPN3)

Alternative Name: CAPN3 (CAPN3 Products)

Synonyms: capn3 antibody, MGC80925 antibody, zgc:92687 antibody, CAPN3 antibody, AI323605 antibody, Capa-3 antibody, Capa3 antibody, Lp82 antibody, p94 antibody, Lp84 antibody, Lp85 antibody, CANP3 antibody, CANPL3 antibody, LGMD2 antibody, LGMD2A antibody, nCL-1 antibody, SKM-CALP antibody, SKM-CALPOV antibody, nCL1 antibody, calpain 1, (mu/I) large subunit L homeolog antibody, calpain 3a, (p94) antibody, calpain 3 antibody, capn1.L antibody, capn3a antibody, CAPN3 antibody, Capn3 antibody

Background: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
Alias Symbols: CANP3, CANPL3, LGMD2, LGMD2A, MGC10767, MGC11121, MGC14344, MGC4403, nCL-1, p94
Protein Interaction Partner: WDYHV1, OSGIN1, NECAB2, DYSF, TTN, YWHAQ, CAPN3, FLNC,
Protein Size: 309

Molecular Weight: 35 kDa

Gene ID: 825

NCBI Accession: NM_173088, NP_775111

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development