Actin antibody (N-Term)
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- Target See all Actin (ACTA1) Antibodies
- Actin (ACTA1) (Actin, alpha 1, Skeletal Muscle (ACTA1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rat, Rabbit, Cow, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Actin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GQKDSYVGDE AQSKRGILTL KYPIEHGIIT NWDDMEKIWH HTFYNELRVA
- Predicted Reactivity
- Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against ACTA1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product ACTA1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 377 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Actin (ACTA1) (Actin, alpha 1, Skeletal Muscle (ACTA1))
- Alternative Name
- ACTA1 (ACTA1 Products)
- Synonyms
- ACTA antibody, ASMA antibody, CFTD antibody, CFTD1 antibody, CFTDM antibody, MPFD antibody, NEM1 antibody, NEM2 antibody, NEM3 antibody, acta antibody, asma antibody, cftd antibody, cftd1 antibody, cftdm antibody, mpfd antibody, nem1 antibody, AA959943 antibody, Acta-2 antibody, Acts antibody, Actsk-1 antibody, actc antibody, actc1 antibody, cfk antibody, hm:zeh0631 antibody, zeh0631 antibody, acta1 antibody, hm:zeh0293 antibody, zgc:112098 antibody, actin, alpha 1, skeletal muscle antibody, actin, alpha 1, skeletal muscle L homeolog antibody, actin, alpha 1b, skeletal muscle antibody, actin, muscle antibody, actin, alpha skeletal muscle antibody, actin, alpha 1a, skeletal muscle antibody, ACTA1 antibody, acta1.L antibody, acta1 antibody, Acta1 antibody, acta1b antibody, LOC100533357 antibody, LOC109479779 antibody, LOC109108280 antibody, acta1a antibody
- Background
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The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
Alias Symbols: ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3
Protein Interaction Partner: ABL1, TRIM63, TRIM55, CEP57, AMOT, UBC, SUMO3, CDKN2A, ACTG1, BRK1, ACTBL2, NCKAP1, LRCH3, MAPK14, DSTN, NMI, UBL4A, ABRA, ABLIM2, POLR1B, RRN3, HTRA2, PTPN22, ABLIM3, BTK, CCT2, TRAF3IP1, TCP1, SNCA, PARK2, LGALS3, SHC1, GSN, CDK2, CUL1, ISG15, YWHAZ, RE
Protein Size: 377 - Molecular Weight
- 42 kDa
- Gene ID
- 58
- NCBI Accession
- NM_001100, NP_001091
- UniProt
- P68133
- Pathways
- Caspase Cascade in Apoptosis, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development
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