ZAP70 antibody (N-Term)
-
- Target See all ZAP70 Antibodies
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Mouse, Rat, Cow, Guinea Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This ZAP70 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
- Predicted Reactivity
- Cow: 79%, Guinea Pig: 79%, Human: 100%, Mouse: 86%, Rat: 79%
- Characteristics
- This is a rabbit polyclonal antibody against ZAP70. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ZAP70
- Top Product
- Discover our top product ZAP70 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 312 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
- Alternative Name
- ZAP70 (ZAP70 Products)
- Synonyms
- SRK antibody, STCD antibody, STD antibody, TZK antibody, ZAP-70 antibody, 70kDa antibody, AI327364 antibody, Srk antibody, mrtle antibody, mur antibody, zap70 antibody, MGC80670 antibody, MGC88962 antibody, ZAP70 antibody, zgc:110383 antibody, zeta chain of T-cell receptor associated protein kinase 70 antibody, putative tyrosine-protein kinase zap-70 antibody, zeta-chain (TCR) associated protein kinase antibody, zeta chain of T cell receptor associated protein kinase 70 antibody, zeta-chain (TCR) associated protein kinase 70kDa antibody, zeta chain of T cell receptor associated protein kinase 70kDa L homeolog antibody, zeta chain of T cell receptor associated protein kinase 70kDa antibody, tyrosine-protein kinase ZAP-70 antibody, ZAP70 antibody, Smp_149470 antibody, Zap70 antibody, zap70.L antibody, zap70 antibody, LOC707555 antibody, LOC100342021 antibody, LOC100390922 antibody, LOC100542877 antibody
- Background
-
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alias Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Protein Interaction Partner: UBC, CSK, PLCG1, ZAP70, CD247, CD3E, LAT, NDUFB8, ERBB3, EGFR, ANAPC11, ASB3, PTPN22, NR0B2, SHC1, GRB2, APP, LCK, CBL, CBLC, LCP2, CBLB, PIK3R1, CD38, HSPA4, TUBB, TUBA1A, VAV1, TUBA1B, tat, NFAM1, DEF6, ACP1, LAX1, FCRL3, PTPN3, DBNL, CARD11, SLA2, SLAM
Protein Size: 312 - Molecular Weight
- 34 kDa
- Gene ID
- 7535
- NCBI Accession
- NM_207519, NP_997402
- UniProt
- P43403
- Pathways
- TCR Signaling, Ubiquitin Proteasome Pathway
-