CARD17 antibody (Middle Region)

Catalog No. ABIN2788724

Product Details anti-CARD17 Antibody

Target: CARD17 (Caspase Recruitment Domain Family, Member 17 (CARD17))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD17 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MDKARALLDS VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CARD17. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CARD17

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 110 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CARD17

Target: CARD17 (Caspase Recruitment Domain Family, Member 17 (CARD17))

Alternative Name: CARD17 (CARD17 Products)

Synonyms: INCA antibody, caspase recruitment domain family member 17 antibody, CARD17 antibody

Background: As a regulator of procaspase-1/CASP1 activation, CARD17 is implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. CARD17 inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, CARD17 do not induce NF-kappa-B activation.
Alias Symbols: INCA
Protein Interaction Partner: CARD17, CARD16, CARD18, CASP1,
Protein Size: 110

Molecular Weight: 12 kDa

Gene ID: 440068

NCBI Accession: NM_001007232, NP_001007233

UniProt: Q5XLA6