GBA antibody (C-Term)

Catalog No. ABIN2788767

Product Details anti-GBA Antibody

Target: GBA (Glucosidase, Beta, Acid (GBA))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Dog, Horse, Rabbit, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EGSQRVGLVA SQKNDLDAVA LMHPDGSAVV VVLNRSSKDV PLTIKDPAVG

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 83%, Pig: 100%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against GBA. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 536 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GBA

Target: GBA (Glucosidase, Beta, Acid (GBA))

Alternative Name: GBA (GBA Products)

Synonyms: GBA1 antibody, GCB antibody, GLUC antibody, BETA-GLUCOSIDASE antibody, T12J13.8 antibody, T12J13_8 antibody, beta glucosidase 25 antibody, PSPTO3318 antibody, PSPTO4290 antibody, GC antibody, GCase antibody, betaGC antibody, glucosylceramidase beta antibody, beta glucosidase 25 antibody, beta-glucosidase antibody, Beta-glucosidase antibody, glucosidase, beta, acid antibody, glucosylceramidase antibody, bglX-2 antibody, GBA antibody, BGLU25 antibody, PSPTO_3318 antibody, bglX antibody, bglA4 antibody, Gba antibody, LOC100399524 antibody, bglA.2 antibody, bglX-2 antibody

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
Alias Symbols: GBA1, GCB, GLUC
Protein Interaction Partner: NUDCD1, UBC, ITCH, ATP6V1B1, SNCA, FBXO6, TCP1, CBL, NEDD4, PARK2, HSP90AA1, HSPA4, PSAP,
Protein Size: 536

Molecular Weight: 59 kDa

Gene ID: 2629

NCBI Accession: NM_000157, NP_000148

UniProt: P04062

Pathways: Cellular Glucan Metabolic Process