Dematin antibody (Middle Region)

Catalog No. ABIN2788873

Product Details anti-Dematin Antibody

Target: Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dematin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KKPPIYKQRE SVGGSPQTKH LIEDLIIESS KFPAAQPPDP NQPAKIETDY

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against EPB49. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 405 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Dematin

Target: Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))

Alternative Name: EPB49 (EPB49 Products)

Synonyms: MGC80597 antibody, MGC108072 antibody, EPB49 antibody, DMT antibody, AI325486 antibody, Epb4.9 antibody, Epb49 antibody, dematin antibody, dematin actin binding protein L homeolog antibody, dematin actin binding protein antibody, dmtn.L antibody, DMTN antibody, dmtn antibody, Dmtn antibody

Background: Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation.
Alias Symbols: DMT, FLJ78462, FLJ98848, EPB49
Protein Interaction Partner: GOLGA2, YWHAB, APP, NEDD4L, SNCA, PTOV1, DYNC1LI2, PRKACA, SNRPD2, PROCR, SPTB, EPB42, ACTB, ACTC1, DISC1,
Protein Size: 405

Molecular Weight: 45 kDa

Gene ID: 2039

NCBI Accession: NM_001978, NP_001969

UniProt: Q08495

Pathways: Regulation of Actin Filament Polymerization