HSD17B8 antibody (N-Term)

Catalog No. ABIN2789035

Product Details anti-HSD17B8 Antibody

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against HSD17B8. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 261 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD17B8

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Alternative Name: HSD17B8 (HSD17B8 Products)

Synonyms: KE6 antibody, fabgl antibody, zgc:112550 antibody, si:dz12f11.4 antibody, HKE6 antibody, FABGL antibody, ke6 antibody, fabg antibody, hke6 antibody, ring2 antibody, h2-ke6 antibody, d6s2245e antibody, D17H6S112E antibody, H-2Ke6 antibody, Hsd17b8 antibody, Ke-6 antibody, Ke6 antibody, Ring2 antibody, D6S2245E antibody, FABG antibody, H2-KE6 antibody, RING2 antibody, SDR30C1 antibody, dJ1033B10.9 antibody, Fabgl antibody, hydroxysteroid (17-beta) dehydrogenase 8 antibody, hydroxysteroid 17-beta dehydrogenase 8 antibody, H2-K region expressed gene 6 antibody, hsd17b8 antibody, HSD17B8 antibody, H2-Ke6 antibody, Hsd17b8 antibody

Background: In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.
Alias Symbols: D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
Protein Interaction Partner: RAD21,
Protein Size: 261

Molecular Weight: 29 kDa

Gene ID: 7923

NCBI Accession: NM_014234, NP_055049

UniProt: Q92506

Pathways: Steroid Hormone Biosynthesis