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HLA-E antibody (Middle Region)

HLA-E Reactivity: Human, Pig, Goat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2789267
  • Target See all HLA-E Antibodies
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Binding Specificity
    • 16
    • 7
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 66
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Pig, Goat
    Host
    • 43
    • 24
    Rabbit
    Clonality
    • 45
    • 22
    Polyclonal
    Conjugate
    • 30
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-E antibody is un-conjugated
    Application
    • 41
    • 27
    • 19
    • 13
    • 13
    • 12
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    DTAAQISEQK SNDASEAEHQ RAYLEDTCVE WLHKYLEKGK ETLLHLEPPK
    Predicted Reactivity
    Goat: 83%, Human: 100%, Pig: 93%
    Characteristics
    This is a rabbit polyclonal antibody against HLA-E. It was validated on Western Blot.
    Purification
    Affinity Purified
    Top Product
    Discover our top product HLA-E Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 358 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Alternative Name
    HLA-E (HLA-E Products)
    Synonyms
    EA1.2 antibody, EA2.1 antibody, HLA-6.2 antibody, MHC antibody, QA1 antibody, major histocompatibility complex, class I, E antibody, HLA-E antibody, PATR-E antibody
    Background
    HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
    Alias Symbols: DKFZp686P19218, EA1.2, EA2.1, HLA-6.2, MHC, QA1
    Protein Interaction Partner: UBC, CALR, TAP2, UBD, PPP1R16A, KLRD1, KLRC2, CD8A, KLRC1, HLA-E, B2M,
    Protein Size: 358
    Molecular Weight
    38 kDa
    Gene ID
    3133
    NCBI Accession
    NM_005516, NP_005507
    UniProt
    P13747
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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