NLRP3 antibody (N-Term)
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- Target See all NLRP3 Antibodies
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
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Binding Specificity
- N-Term
- Reactivity
- Human, Dog, Cow, Rabbit, Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NLRP3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LGESVSLNKR YTRLRLIKEH RSQQEREQEL LAIGKTKTCE SPVSPIKMEL
- Predicted Reactivity
- Cow: 93%, Dog: 79%, Horse: 93%, Human: 100%, Pig: 93%, Rabbit: 79%
- Characteristics
- This is a rabbit polyclonal antibody against NLRP3. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product NLRP3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1036 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
- Alternative Name
- NLRP3 (NLRP3 Products)
- Synonyms
- CIAS1 antibody, Nalp3 antibody, avp antibody, cias1 antibody, nalp3 antibody, pypaf1 antibody, agtavprl antibody, AGTAVPRL antibody, AII antibody, AVP antibody, C1orf7 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, AII/AVP antibody, Cias1 antibody, Mmig1 antibody, Pypaf1 antibody, NLR family pyrin domain containing-like antibody, NLR family pyrin domain containing 3 antibody, NLR family, pyrin domain containing 3 L homeolog antibody, NLR family, pyrin domain containing 3 antibody, NLRPL antibody, NLRP3 antibody, nlrp3.L antibody, Nlrp3 antibody
- Background
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This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
Alias Symbols: AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, FLJ95925, MWS, NALP3, PYPAF1
Protein Interaction Partner: DHX33, FAF1, SUGT1, HSP90AA1, CARD8, PYCARD, NLRC4,
Protein Size: 1036 - Molecular Weight
- 114 kDa
- Gene ID
- 114548
- NCBI Accession
- NM_004895, NP_004886
- UniProt
- Q96P20
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
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