HAS1 antibody (N-Term)
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- Target See all HAS1 Antibodies
- HAS1 (Hyaluronan Synthase 1 (HAS1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HAS1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EPAAAGAVGA GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against HAS1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product HAS1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 578 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HAS1 (Hyaluronan Synthase 1 (HAS1))
- Alternative Name
- HAS1 (HAS1 Products)
- Synonyms
- dg42 antibody, Xhas1 antibody, HAS antibody, shas1 antibody, hyaluronan synthase 1 antibody, hyaluronan synthase 1 S homeolog antibody, has1 antibody, HAS1 antibody, Has1 antibody, has1.S antibody
- Background
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Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.
Alias Symbols: HAS
Protein Interaction Partner: EWSR1, DDX1, VHL, EIF6,
Protein Size: 578 - Molecular Weight
- 64 kDa
- Gene ID
- 3036
- NCBI Accession
- NM_001523, NP_001514
- UniProt
- Q92839
- Pathways
- Glycosaminoglycan Metabolic Process
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