FPGS antibody (Middle Region)

Catalog No. ABIN2789500

Product Details anti-FPGS Antibody

Target: FPGS (Folylpolyglutamate Synthase (FPGS))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FPGS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: CWLQRQDRHG AGEPKASRPG LLWQLPLAPV FQPTSHMRLG LRNTEWPGRT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against FPGS. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 537 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FPGS antibody (ABIN2789500)

Fukuda, Oguri, Kunii, Sone, Uemura, Takakuwa, Maeno, Kanemitsu, Ohkubo, Takemura, Ito, Niimi: "A folylpoly-γ-glutamate synthase single nucleotide polymorphism associated with response to pemetrexed treatment combined with platinum for non-small cell lung cancer." in: Lung cancer (Amsterdam, Netherlands), Vol. 102, pp. 15-20, (2016) (PubMed).

Target Details for FPGS

Target: FPGS (Folylpolyglutamate Synthase (FPGS))

Alternative Name: FPGS (FPGS Products)

Synonyms: zgc:63807 antibody, wu:fk49h03 antibody, wu:fk51d09 antibody, FPGS antibody, fpgS antibody, SCC88.25c antibody, BA4689 antibody, AA408187 antibody, folylpolyglutamate synthase antibody, dihydrofolate synthase antibody, folylpolyglutamate synthase, mitochondrial antibody, folylpolyglutamyl synthetase antibody, fpgs antibody, fpgS antibody, FPGS antibody, SCO2614 antibody, fgs antibody, folC antibody, CpipJ_CPIJ008043 antibody, Fpgs antibody

Background: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
Alias Symbols: -
Protein Interaction Partner: UBC,
Protein Size: 537

Molecular Weight: 59 kDa

Gene ID: 2356

NCBI Accession: NM_001018078, NP_001018088

UniProt: Q5JU19