SHANK2 antibody (C-Term)

Catalog No. ABIN2789713

Product Details anti-SHANK2 Antibody

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DLVKQKKSDT PQSPSLNSSQ PTNSADSKKP ASLSNCLPAS FLPPPESFDA

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 86%, Human: 100%, Mouse: 77%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SHANK2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1153 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Alternative Name: SHANK2 (SHANK2 Products)

Synonyms: AUTS17 antibody, CORTBP1 antibody, CTTNBP1 antibody, ProSAP1 antibody, SHANK antibody, SPANK-3 antibody, mKIAA1022 antibody, auts17 antibody, cortbp1 antibody, cttnbp1 antibody, prosap1 antibody, spank-3 antibody, shank2 antibody, MGC122482 antibody, CortBP1 antibody, Spank-3 antibody, SHANK2 antibody, SH3 and multiple ankyrin repeat domains 2 antibody, SH3 and multiple ankyrin repeat domains 2 L homeolog antibody, SH3 and multiple ankyrin repeat domains protein 2 antibody, SHANK2 antibody, Shank2 antibody, shank2.L antibody, shank2 antibody, LOC100438523 antibody

Background: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
Alias Symbols: AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Protein Interaction Partner: SHARPIN, NLK, LPHN1, DLGAP1, LPHN2, ARHGEF7, BAIAP2, DLG4, BAI2, DNM2, SSTR2, SLC9A3, CTTN, DLGAP3, DLGAP4, DLGAP2, DYNLL2, DYNLL1, MYO5A,
Protein Size: 1153

Molecular Weight: 126 kDa

Gene ID: 22941

NCBI Accession: NM_012309