PDE8B antibody (Middle Region)

Catalog No. ABIN2789902

Product Details anti-PDE8B Antibody

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Horse, Cow, Dog, Pig, Guinea Pig, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TELYSPQLGT KDEDPHTSDL VGGLMTDGLR RLSGNEYVFT KNVHQSHSHL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PDE8B. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 788 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B (PDE8B Products)

Synonyms: PDE8B antibody, ADSD antibody, PPNAD3 antibody, B230331L10Rik antibody, C030047E14Rik antibody, RNPDE8B antibody, phosphodiesterase 8B antibody, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody, PDE8B antibody, LOC100468338 antibody, pde8b antibody, Pde8b antibody

Background: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ADSD, FLJ11212, PPNAD3
Protein Interaction Partner: UBC,
Protein Size: 788

Molecular Weight: 87 kDa

Gene ID: 8622

NCBI Accession: NM_001029851, NP_001025022

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process