TXNRD3 antibody (N-Term)

Catalog No. ABIN2789948

Product Details anti-TXNRD3 Antibody

Target: TXNRD3 (Thioredoxin Reductase 3 (TXNRD3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LSPPGRRARL SSPGPSRSSE AREELRRHLV GLIERSRVVI FSKSYCPHST

Predicted Reactivity: Human: 100%, Mouse: 86%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against TXNRD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TXNRD3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 643 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TXNRD3

Target: TXNRD3 (Thioredoxin Reductase 3 (TXNRD3))

Alternative Name: TXNRD3 (TXNRD3 Products)

Background: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: TGR, TR2, TRXR3
Protein Interaction Partner: UBC,
Protein Size: 643

Molecular Weight: 70 kDa

Gene ID: 114112

NCBI Accession: NM_052883, NP_443115

UniProt: Q86VQ6

Pathways: Cell RedoxHomeostasis