TNK1 antibody (C-Term)

Catalog No. ABIN2790058

Product Details anti-TNK1 Antibody

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Binding Specificity: C-Term

Reactivity: Human, Guinea Pig, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EIRQARAVPQ GPPGLPPRPP LSSSSPQPSQ PSRERLPWPK RKPPHNHPMG

Predicted Reactivity: Guinea Pig: 83%, Human: 100%, Pig: 85%, Rabbit: 77%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against TNK1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 661 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Alternative Name: TNK1 (TNK1 Products)

Synonyms: Kos1 antibody, Tnk1a antibody, Tnk1b antibody, Ack-like antibody, tyrosine kinase non receptor 1 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK1 antibody, Tnk1 antibody

Background: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: MGC46193
Protein Interaction Partner: HSP90AA1, UBC, PLCG1, TNK1, SFN,
Protein Size: 661

Molecular Weight: 72 kDa

Gene ID: 8711

NCBI Accession: NM_003985, NP_003976

UniProt: Q13470