MOB1A antibody (C-Term)

Catalog No. ABIN2790218

Product Details anti-MOB1A Antibody

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOB1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FDSVMQLQEE AHLNTSFKHF IFFVQEFNLI DRRELAPLQE LIEKLGSKDR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against MOB1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MOB1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 216 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MOB1A

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Alternative Name: MOB1A (MOBKL1B Products)

Synonyms: mob1 antibody, mob4b antibody, MOB1A antibody, MOBK1B antibody, MOB1 antibody, mats1 antibody, mobk1b antibody, mobkl1b antibody, MOBKL1B antibody, wu:fv69d04 antibody, zgc:56189 antibody, C2orf6 antibody, MATS1 antibody, Mob4B antibody, 4022402H07Rik antibody, MOB4B antibody, Mobk1b antibody, Mobkl1b antibody, MOB kinase activator 1A L homeolog antibody, MOB kinase activator 1A antibody, MOB kinase activator 1A pseudogene antibody, mob1a.L antibody, MOB1A antibody, mob1a antibody, LOC712156 antibody, Mob1a antibody

Background: MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38.
Alias Symbols: C2orf6, FLJ10788, FLJ11595, MATS1, MOB1, MOBK1B, Mob4B, MOBKL1B
Protein Interaction Partner: FAM9B, CMTM3, SEPT3, FAM118A, KANK2, TDO2, UBC, HECW2, ANKRD52, AMOT, ANKRD44, DOCK7, LRCH3, RASSF5, DOCK8, MOB2, SAV1, LRCH2, DOCK6, THOC2, PPP6R3, CRLF3, IPO11, LATS2, ANKRD28, LRCH1, STK38L, PPP6R1, RASSF2, PPP6R2, LATS1, YWHAH, STK4, STK3, PTPN14, PPP
Protein Size: 216

Molecular Weight: 25 kDa

Gene ID: 55233

NCBI Accession: NM_018221, NP_060691

UniProt: Q9H8S9