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SPAG1 antibody (N-Term)

SPAG1 Reactivity: Human, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2790231
  • Target See all SPAG1 Antibodies
    SPAG1 (Sperm Associated Antigen 1 (SPAG1))
    Binding Specificity
    • 10
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 29
    • 1
    • 1
    Human, Dog
    Host
    • 28
    • 1
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPAG1 antibody is un-conjugated
    Application
    • 21
    • 16
    • 16
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH
    Predicted Reactivity
    Dog: 85%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SPAG1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of human SPAG1
    Top Product
    Discover our top product SPAG1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SPAG1 (Sperm Associated Antigen 1 (SPAG1))
    Alternative Name
    SPAG1 (SPAG1 Products)
    Synonyms
    cb1089 antibody, MGC162178 antibody, wu:fj78g10 antibody, sp75 antibody, tpis antibody, hsd-3.8 antibody, HSD-3.8 antibody, SP75 antibody, TPIS antibody, sperm associated antigen 1 antibody, sperm associated antigen 1a antibody, SPAG1 antibody, spag1a antibody, CpipJ_CPIJ006297 antibody, spag1 antibody, Spag1 antibody
    Background
    The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
    Alias Symbols: SP75, TPIS, CT140, CILD28, HSD-3.8, HEL-S-268
    Protein Size: 416
    Molecular Weight
    45 kDa
    Gene ID
    6674
    NCBI Accession
    NM_003114, NP_003105
    UniProt
    G3XAM3
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