Importin 8 antibody (C-Term)

Catalog No. ABIN2790260

Product Details anti-Importin 8 Antibody

Target: Importin 8 (IPO8)

Binding Specificity: C-Term

Reactivity: Human, Rat, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPAVDAVVGQ IVPSILFLFL GLKQVCATRQ LVNREDRSKA EKADMEENEE

Predicted Reactivity: Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IPO8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IPO8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 832 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Importin 8

Target: Importin 8 (IPO8)

Alternative Name: IPO8 (IPO8 Products)

Background: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ26580, RANBP8
Protein Interaction Partner: UBC, EGFR, YWHAE, CBX5, ATXN1, CUL3, Trim28, AGO4, AGO3, AGO2, AGO1, KPNB1, RANGAP1, SRP19, RPL23A,
Protein Size: 832

Molecular Weight: 96 kDa

Gene ID: 10526

NCBI Accession: NM_001190995, NP_001177924

UniProt: O15397