CHMP5 antibody (C-Term)

Catalog No. ABIN2790285

Product Details anti-CHMP5 Antibody

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LDALGDELLA DEDSSYLDEA ASAPAIPEGV PTDTKNKDGV LVDEFGLPQI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 80%

Characteristics: This is a rabbit polyclonal antibody against Chmp5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Chmp5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 219 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHMP5

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Alternative Name: Chmp5 (CHMP5 Products)

Synonyms: SNF7DC2 antibody, cgi-34 antibody, hspc177 antibody, pnas-2 antibody, vps60 antibody, chmp5 antibody, zgc:64125 antibody, C9orf83 antibody, HSPC177 antibody, PNAS-2 antibody, Vps60 antibody, 2210412K09Rik antibody, AW545668 antibody, RGD1305968 antibody, charged multivesicular body protein 5 S homeolog antibody, charged multivesicular body protein 5b antibody, charged multivesicular body protein 5 antibody, charged multivesicular body protein 5 L homeolog antibody, chromatin modifying protein 5 antibody, chmp5.S antibody, chmp5b antibody, CHMP5 antibody, chmp5.L antibody, chmp5 antibody, Chmp5 antibody

Background: Chmp5 is a probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Alias Symbols: 2210412K09Rik, AW545668
Protein Interaction Partner: Ndn,
Protein Size: 219

Molecular Weight: 24 kDa

Gene ID: 76959

NCBI Accession: NM_029814, NP_084090

UniProt: Q9D7S9