IYD antibody (N-Term)

Catalog No. ABIN2790550

Product Details anti-IYD Antibody

Target: IYD (Iodotyrosine Deiodinase (IYD))

Binding Specificity: N-Term

Reactivity: Human, Rat, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IYD antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NADRSMEKKK GEPRTRAEAR PWVDEDLKDS SDLHQAEEDA DEWQESEENV

Predicted Reactivity: Cow: 77%, Dog: 79%, Human: 100%, Rabbit: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against IYD. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human IYD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 247 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IYD

Target: IYD (Iodotyrosine Deiodinase (IYD))

Alternative Name: IYD (IYD Products)

Synonyms: MGC85450 antibody, C6orf71 antibody, DEHAL1 antibody, TDH4 antibody, dJ422F24.1 antibody, 0610009A07Rik antibody, AI265638 antibody, Dehal1 antibody, RGD1309288 antibody, IYD-1 antibody, iodotyrosine deiodinase antibody, iodotyrosine deiodinase L homeolog antibody, IYD antibody, iyd.L antibody, iyd antibody, Iyd antibody

Background: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.
Alias Symbols: C6orf71, DEHAL1, TDH4, dJ422F24.1
Protein Interaction Partner: TRIM69,
Protein Size: 247

Molecular Weight: 27 kDa

Gene ID: 389434

NCBI Accession: NM_001164695, NP_001158167

Pathways: Thyroid Hormone Synthesis