CCDC99 antibody (C-Term)

Catalog No. ABIN2790740

Product Details anti-CCDC99 Antibody

Target: CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))

Binding Specificity: C-Term

Reactivity: Human, Rat, Rabbit, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC99 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PRLAAESKLQ TEVKEGKETS SKLEKETCKK LHPILYVSSK STPETQCPQQ

Predicted Reactivity: Cow: 79%, Dog: 93%, Horse: 92%, Human: 100%, Pig: 93%, Rabbit: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against CCDC99. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CCDC99

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 605 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CCDC99

Target: CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))

Alternative Name: CCDC99 (CCDC99 Products)

Synonyms: CCDC99 antibody, CG15415 antibody, Dmel\\CG15415 antibody, SPINDLY antibody, ccdc99 antibody, 1700018I02Rik antibody, 2600001J17Rik antibody, 2810049B11Rik antibody, AA409762 antibody, Ccdc99 antibody, RGD1306908 antibody, ccdc99-a antibody, ccdc99-b antibody, spdl1-a antibody, spdl1-b antibody, spdl1 antibody, spindle apparatus coiled-coil protein 1 antibody, CG15415 gene product from transcript CG15415-RB antibody, Tetratricopeptide repeat (TPR)-like superfamily protein antibody, spindle apparatus coiled-coil protein 1 L homeolog antibody, spindle apparatus coiled-coil protein 1 S homeolog antibody, SPDL1 antibody, Spindly antibody, SPY antibody, spdl1 antibody, Spdl1 antibody, spdl1.L antibody, spdl1.S antibody

Background: CCDC99 is required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. CCDC99 is also required for correct spindle orientation. It does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
Alias Symbols: FLJ20364, FLJ40690, CCDC99
Protein Interaction Partner: RTP5, PPP1R18, DYX1C1, SPDL1, USP15, TRAF4, CA8, NEK9, SIRT1, HMGCS1, DHX40, YLPM1, SF3B3, ITSN1, UBC, KIAA1377, GPS2,
Protein Size: 605

Molecular Weight: 67 kDa

Gene ID: 54908

NCBI Accession: NM_017785, NP_060255

UniProt: Q96EA4