KDELR2 antibody (C-Term)

Catalog No. ABIN2790796

Product Details anti-KDELR2 Antibody

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDELR2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ASVLQGARTE FLPQQRHKML DTENQKLNSF VADSHQWLCK NAEEKSQKVS

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KDELR2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDELR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 186 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KDELR2

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Alternative Name: KDELR2 (KDELR2 Products)

Synonyms: kdelr2 antibody, ELP-1 antibody, ERD2.2 antibody, 1110007A14Rik antibody, kdelr1-a antibody, KDEL endoplasmic reticulum protein retention receptor 2 L homeolog antibody, KDEL endoplasmic reticulum protein retention receptor 2 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 antibody, KDEL endoplasmic reticulum protein retention receptor 1 L homeolog antibody, kdelr2.L antibody, KDELR2 antibody, Kdelr2 antibody, kdelr1.L antibody

Background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83 % identical to the KDELR1 gene product.
Alias Symbols: ELP-1, ERD2.2, FLJ45532
Protein Interaction Partner: UBC, ELAVL1, SERINC3,
Protein Size: 186

Molecular Weight: 21 kDa

Gene ID: 11014

NCBI Accession: NM_001100603, NP_001094073

Pathways: Maintenance of Protein Location