DENND1C antibody (C-Term)

Catalog No. ABIN2790995

Product Details anti-DENND1C Antibody

Target: DENND1C (DENN/MADD Domain Containing 1C (DENND1C))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DENND1C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PSSLEDPRAR PPKALLAERA HLQPREEPGA LNSPATPTSN CQKSQPSSRP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DENND1C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DENND1C

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 801 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DENND1C

Target: DENND1C (DENN/MADD Domain Containing 1C (DENND1C))

Alternative Name: DENND1C (DENND1C Products)

Synonyms: FAM31C antibody, 4432409M07Rik antibody, DENN/MADD domain containing 1C L homeolog antibody, DENN/MADD domain containing 1C antibody, DENN domain containing 1C antibody, dennd1c.L antibody, DENND1C antibody, Dennd1c antibody

Background: Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 and bind to clathrin and clathrin adaptor protein-2. Thus, connecdenns link RAB35 activation with the clathrin machinery.
Alias Symbols: FAM31C
Protein Interaction Partner: APP, ELAVL1,
Protein Size: 801

Molecular Weight: 87 kDa

Gene ID: 79958

NCBI Accession: NM_024898, NP_079174

UniProt: Q8IV53