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Osteoprotegerin antibody (N-Term)

TNFRSF11B Reactivity: Human, Mouse, Rat, Rabbit, Dog, Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792104
  • Target See all Osteoprotegerin (TNFRSF11B) Antibodies
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Binding Specificity
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Rabbit, Dog, Pig, Horse
    Host
    • 49
    • 12
    • 2
    • 1
    Rabbit
    Clonality
    • 53
    • 11
    Polyclonal
    Conjugate
    • 42
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Osteoprotegerin antibody is un-conjugated
    Application
    • 48
    • 29
    • 26
    • 18
    • 11
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    LDISIKWTTQ ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV
    Predicted Reactivity
    Dog: 78%, Horse: 78%, Human: 100%, Mouse: 85%, Pig: 78%, Rabbit: 78%, Rat: 78%
    Characteristics
    This is a rabbit polyclonal antibody against TNFRSF11B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF11B
    Top Product
    Discover our top product TNFRSF11B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 401 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
    Alternative Name
    TNFRSF11B (TNFRSF11B Products)
    Synonyms
    CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, OCIF antibody, OPG antibody, TR1 antibody, Opg antibody, ocif antibody, opg antibody, tr1 antibody, TNF superfamily member 11 antibody, TNF receptor superfamily member 11b antibody, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) antibody, TNF receptor superfamily member 11B antibody, tumor necrosis factor receptor superfamily member 11b S homeolog antibody, tumor necrosis factor receptor superfamily, member 11b antibody, TNFSF11 antibody, TNFRSF11B antibody, Tnfrsf11b antibody, tnfrsf11b.S antibody
    Target Type
    Chemical
    Background
    TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
    Alias Symbols: OPG, TR1, OCIF
    Protein Interaction Partner: TNFSF13, TNFSF10, TNFSF11, VWF, VTN, THBS1, FN1,
    Protein Size: 401
    Molecular Weight
    46 kDa
    Gene ID
    4982
    NCBI Accession
    NM_002546, NP_002537
    UniProt
    O00300
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