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CDK6 antibody (C-Term)

CDK6 Reactivity: Human, Mouse, Cow, Dog, Horse, Rabbit, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792149
  • Target See all CDK6 Antibodies
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Binding Specificity
    • 22
    • 21
    • 14
    • 10
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 126
    • 47
    • 25
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Cow, Dog, Horse, Rabbit, Pig
    Host
    • 109
    • 17
    Rabbit
    Clonality
    • 98
    • 28
    Polyclonal
    Conjugate
    • 67
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDK6 antibody is un-conjugated
    Application
    • 75
    • 38
    • 29
    • 27
    • 27
    • 24
    • 23
    • 13
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    LLKCLTFNPA KRISAYSALS HPYFQDLERC KENLDSHLPP SQNTSELNTA
    Predicted Reactivity
    Cow: 84%, Dog: 84%, Horse: 84%, Human: 100%, Mouse: 76%, Pig: 84%, Rabbit: 84%
    Characteristics
    This is a rabbit polyclonal antibody against CDK6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human CDK6
    Top Product
    Discover our top product CDK6 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 326 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
    Alternative Name
    CDK6 (CDK6 Products)
    Synonyms
    CDK6 antibody, PLSTIRE antibody, 5830411I20 antibody, AI504062 antibody, Crk2 antibody, cyclin dependent kinase 6 antibody, cyclin-dependent kinase 6 antibody, CDK6 antibody, Cdk6 antibody
    Background
    CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.
    Alias Symbols: MGC59692, PLSTIRE
    Protein Interaction Partner: PSMA3, DAB1, CDKN2D, CDKN2C, CDKN2B, CCND3, UBC, CCND2, AMY2A, CDKN2A, CDK6, PIGR, DMBT1, WDR33, CDKL3, RB1, CDK4, UCHL1, PML, NUMA1, NFATC3, MYC, MLLT3, MEF2D, MCM2, ISL1, HSP90AA1, HSF1, FOXO3, FOXM1, EZH2, ELK1, DDIT3, ATF6B, CDKN1A, CDC6, CCND1, ZSCAN
    Protein Size: 326
    Molecular Weight
    37 kDa
    Gene ID
    1021
    NCBI Accession
    NM_001259, NP_001250
    UniProt
    Q00534
    Pathways
    Cell Division Cycle, Mitotic G1-G1/S Phases
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