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MDM4-binding Protein antibody (N-Term)

MDM4 Reactivity: Human, Cow, Pig, Rabbit, Dog, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792185
  • Target See all MDM4-binding Protein (MDM4) Antibodies
    MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
    Binding Specificity
    • 15
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 61
    • 41
    • 20
    • 2
    • 2
    • 2
    • 1
    Human, Cow, Pig, Rabbit, Dog, Horse
    Host
    • 66
    • 9
    • 2
    Rabbit
    Clonality
    • 71
    • 7
    Polyclonal
    Conjugate
    • 36
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MDM4-binding Protein antibody is un-conjugated
    Application
    • 57
    • 33
    • 13
    • 13
    • 12
    • 11
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA
    Predicted Reactivity
    Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%
    Characteristics
    This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4
    Top Product
    Discover our top product MDM4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 490 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt, Kleeff, Ehemann, Eils, Lichter, Schirmacher, Radlwimmer: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." in: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).

  • Target
    MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
    Alternative Name
    MDM4 (MDM4 Products)
    Synonyms
    mdmx antibody, HDMX antibody, MDMX antibody, MRP1 antibody, wu:fa09h09 antibody, wu:fi33d10 antibody, 4933417N07Rik antibody, AA414968 antibody, AL023055 antibody, AU018793 antibody, AU021806 antibody, C85810 antibody, Mdmx antibody, MDM4, p53 regulator S homeolog antibody, MDM4, p53 regulator antibody, transformed mouse 3T3 cell double minute 4 antibody, mdm4.S antibody, MDM4 antibody, Mdm4 antibody, mdm4 antibody
    Background
    MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX
    Protein Interaction Partner: RNF115, CAPN7, CD160, MDM2, TP53, UBC, MDM4, USP2, YWHAG, UBE2D2, PRKAA1, BCL2, RPS20, RPS15, RPL37, YWHAQ, HSP90AA1, CSNK1A1, PPP1CC, PPP1CB, PPP1CA, RB1, APP, UBE2D3, UBE2D1, MNAT1, ABL1, LRSAM1, TRIM55, TRIM46, MKRN3, YWHAZ, YWHAE, YWHAB, CDKN1A, RFWD2
    Protein Size: 490
    Molecular Weight
    55 kDa
    Gene ID
    4194
    NCBI Accession
    NM_002393, NP_002384
    UniProt
    O15151
    Pathways
    Cell Division Cycle
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