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CCL2 antibody (Middle Region)

CCL2 Reactivity: Human, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792200
  • Target See all CCL2 Antibodies
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Binding Specificity
    • 24
    • 15
    • 13
    • 10
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 99
    • 61
    • 59
    • 18
    • 18
    • 18
    • 16
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Dog
    Host
    • 119
    • 56
    • 8
    • 7
    • 3
    • 2
    • 2
    Rabbit
    Clonality
    • 135
    • 62
    Polyclonal
    Conjugate
    • 110
    • 33
    • 14
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CCL2 antibody is un-conjugated
    Application
    • 138
    • 69
    • 56
    • 28
    • 26
    • 25
    • 24
    • 18
    • 15
    • 13
    • 13
    • 13
    • 12
    • 11
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    ASYRRITSSK CPKEAVIFKT IVAKEICADP KQKWVQDSMD HLDKQTQTPK
    Predicted Reactivity
    Dog: 75%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CCL2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CCL2
    Top Product
    Discover our top product CCL2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 99 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Alternative Name
    CCL2 (CCL2 Products)
    Synonyms
    GDCF-2 antibody, HC11 antibody, HSMCR30 antibody, MCAF antibody, MCP-1 antibody, MCP1 antibody, SCYA2 antibody, SMC-CF antibody, AI323594 antibody, JE antibody, Scya2 antibody, Sigje antibody, MCP-1A antibody, MCP1A antibody, C-C motif chemokine ligand 2 antibody, chemokine (C-C motif) ligand 2 antibody, C-C motif chemokine 2 antibody, CCL2 antibody, Ccl2 antibody, LOC101120093 antibody
    Background
    CCL2 is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. CCL2 augments monocyte anti-tumor activity. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. CCL2 may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: GDCF-2, GDCF-2 HC11, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
    Protein Interaction Partner: Ccr2, CDC45, PCNA, ORC4, ORC2, MCM7, MCM3, MCM2, CDC6, ACKR2, ACKR4, CCR5, CCR1, CCR10, MMP3, CCL2, MMP8, MMP1, VCAN, ACKR1, CCL5, CCR3,
    Protein Size: 99
    Molecular Weight
    11 kDa
    Gene ID
    6347
    NCBI Accession
    NM_002982, NP_002973
    UniProt
    P13500
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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