CCL18 antibody (Middle Region)

Catalog No. ABIN2792202

Product Details anti-CCL18 Antibody

Target: CCL18 (Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated) (CCL18))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PQKFIVDYSE TSPQCPKPGV ILLTKRGRQI CADPNKKWVQ KYISDLKLNA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CCL18. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCL18

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 89 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CCL18 antibody (ABIN2792202)

Schraufstatter, Takamori, Sikora, Sriramarao, DiScipio: "Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 286, Issue 3, pp. L494-501, (2004) (PubMed).

Target Details for CCL18

Target: CCL18 (Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated) (CCL18))

Alternative Name: CCL18 (CCL18 Products)

Synonyms: H7AP1 antibody, PARC antibody, RP3-330M21.2 antibody, AMAC-1 antibody, AMAC1 antibody, CKb7 antibody, DC-CK1 antibody, DCCK1 antibody, MIP-4 antibody, SCYA18 antibody, cullin 9 antibody, C-C motif chemokine ligand 18 antibody, CUL9 antibody, CCL18 antibody

Background: CCL18 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by CCL18 displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
Alias Symbols: CKb7, PARC, AMAC1, DCCK1, MIP-4, AMAC-1, DC-CK1, SCYA18
Protein Interaction Partner: C14orf1, UNC119, CRMP1, TLE1, TP53, EEF1A1,
Protein Size: 89

Molecular Weight: 10 kDa

Gene ID: 6362

NCBI Accession: NM_002988, NP_002979

UniProt: P55774