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DOK1 antibody (C-Term)

DOK1 Reactivity: Human, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792206
  • Target See all DOK1 Antibodies
    DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))
    Binding Specificity
    • 33
    • 29
    • 9
    • 8
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 93
    • 51
    • 38
    • 7
    • 6
    • 6
    • 3
    • 2
    Human, Horse
    Host
    • 107
    • 2
    Rabbit
    Clonality
    • 107
    • 2
    Polyclonal
    Conjugate
    • 47
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This DOK1 antibody is un-conjugated
    Application
    • 90
    • 37
    • 34
    • 18
    • 13
    • 13
    • 13
    • 10
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST
    Predicted Reactivity
    Horse: 84%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against DOK1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1
    Top Product
    Discover our top product DOK1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 481 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))
    Alternative Name
    DOK1 (DOK1 Products)
    Synonyms
    P62DOK antibody, Dok-1 antibody, AW557123 antibody, p62DOK antibody, dok1 antibody, zgc:76914 antibody, docking protein 1 antibody, docking protein 1b antibody, DOK1 antibody, Dok1 antibody, dok1b antibody
    Background
    DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
    Alias Symbols: MGC117395, MGC138860, P62DOK
    Protein Interaction Partner: UBC, RASA1, ABL1, CD28, Nck1, Syngap1, INSR, CRKL, BCR, Dlg4, gag-pol, ERBB2, VAV1, SRC, SHC1, PTK6, PIK3R1, ITK, FGR, CRK, ABL2, CBLL1, INPP5D, NCK2, MAP4K4, PTPRH, GRB10, TEC, ITGB2, SH2D1A, FES, PTPN6, ITGB3, PLCG1, LYN, KIT, YES1, RET, LCK, ITGB5, ITG
    Protein Size: 481
    Molecular Weight
    53 kDa
    Gene ID
    1796
    NCBI Accession
    NM_001381, NP_001372
    UniProt
    Q99704
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